RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination

Abstract RNF2 is a RING domain-containing E3 ubiquitin ligase that mediate histone H2A mono-ubiquitination to repress gene transcription, but its expression patterns and molecular function in hepatocellular carcinoma (HCC) remain unclear.Herein, we extracted data from TGCA database and validated RNF2 expression ivoryjinelle.com in our own cohort, w

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Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts

Differential regulation has been suggested for cellular cholesterol and phospholipid release mediated by apolipoprotein A-I (apoA-I)/ABCA1.We investigated various factors involved in cholesterol mobilization related to this pathway.ApoA-I induced a rapid decrease of the cellular cholesterol compartment that is in equilibrium with the ACAT-accessibl

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Unmasking N95 for COVID-19 health-care workers in India

A general term N95 Mask has been widely used by all including the health care personnel.It has been use incorrectly by here all and it should be replaced with the term filtering facepiece respirator.There are two types of respirators being used in the world.One is the industrial type whereas the other one is the medical surgical one.The medical sur

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